Rheumatology & Clinical Immunology is the medical super-specialty that deals with arthritis, diseases of musculoskeletal system and connective tissue disorders or autoimmune disorders. There are at least 100 different types of arthritis and rheumatism. Rheumatoid arthritis develops in about 1% in the whole world’s population. Women are affected 2 times more than men. It appears in the age group between 35 to 50years. A similar disease in children may occur which is known as Juvenile idiopathic arthritis.Lupus is a chronic inflammatory disease with many health risks like cardiovascular disease, kidney disease and stroke. There is a chance of developing atherosclerosis, mayocarditis and endocarditis, which can lead to heart murmurs.Osteoporosis is a very common health issue that upsets everyone. The person should not wait until it breaks into their routine before taking action; it is never too early or too late to start taking care of the bones’ health. Juvenile idiopathic arthritis can give rise to critical problems, such as growth and development problems, joint damage, and eye inflammation. Treatment is given to reduce pain and inflammation, improving the function of the joints, and preventing any further joint damage.Sjögren’s syndrome is an autoimmune disease in which our own body immune system attacks glands that produce moisture. The misdirected immune system leads to inflammation of tissues and dysfunction in glands of the body that are generating tears and saliva.