Drug discovery and development is a complex and time intensive process that requires a significant amount of resources and capital investments (~USD 2.6 billion). In fact, on an average, the journey from establishment of initial proof-of-concept to product launch, takes around 10-12 years. Moreover, regulatory approval is dependent on the results of randomized clinical trials (RCTs), which are estimated to account for a staggering 40% of the pharmaceutical industry’s budget in the US.
The “Biopharmaceutical Contract Manufacturing Market (4th Edition) by Type of Product (API, FDF), Scale of Operations (Preclinical, Clinical and Commercial), Expression System (Mammalian, Microbial and Others), Company Size (Small, Mid-sized, Large and Very Large), Biologics (Antibody, Vaccine, Cell Therapy and Other Biologics) and Key Geographical Regions (North America, Europe, Asia-Pacific, MENA and LATAM)- Industry Trends and Global Forecast to 2030” report features an extensive study on the contract service providers within the biopharmaceutical industry. The study features in-depth analyses, highlighting the capabilities of a diverse set of biopharmaceutical CMOs and contract development and manufacturing organizations (CDMOs).
In 2018, it was estimated that the availability of low-cost, generic versions of pharmaceutical interventions saved nearly USD 1.6 trillion in healthcare costs in the US over the last decade. Given the cost benefits offered, generic medicines usually have high adoption rates. Moreover, upcoming patent expiries of several blockbuster drugs, such as LYRICA®, Cialis®, Advair® and Sensipar®, have intensified the interest of several drug manufacturers in the development of generics. As more generic drugs get approved by regulators across the globe, the competition in the industry has steadily increased. Interestingly, in 2018, the US FDA approved more than 780 generic products, which represented more than 90% increase in the number of such drug approvals since 2014. The most evident impact of the growth in competition in this domain is deflation of cost of generics, resulting in diminished profit margins for the developers of such products. Therefore, to ensure sustainable growth within the off-patent drug products market, companies are gradually adopting innovative drug alteration techniques in order to develop value added medicinal products, which offer better commercial benefits.
According to the World Bank, more than 50,000 different types of medical devices are currently being used on a daily basis in healthcare facilities across the globe. In 2018, the global medical devices market was estimated to have reached a net worth of approximately USD 450 billion. It is also worth noting that, since in the same year, the USFDA approved over 130 medical devices.
At present, the wholesale colocation datacenters are being preferred by the large enterprises and are witnessing significant growth in the developed and developing regions of Asia Pacific, Europe and North America. The need for easy scalability and secure datacenter is driving the growth of the wholesale datacenters.
[COVID-19 SERIES] Advances in DNA sequencing technologies have led to significant developments in a variety of healthcare-focused research fields, such as precision medicine and diagnostics. Particularly, the impact of next generation sequencing (NGS) methods, enabling whole genome and whole exome sequencing, has been the most profound.
Sun damage can be an ugly thing to deal with, but it doesn’t have to be. There are things you can do to help keep it from worsening and to make sure it stays local. Whether you are at home or away, it is important to protect yourself from the dangers of sun damage. Many people don’t realize how damaging UV rays are until they get severe skin issues. It is important to take the necessary steps to prevent this from happening to you. One of the best ways is by finding out the places that expose you to the most sun damage.
One of the biggest areas that expose you to sun damage is your roof. It is best to seal up any gaps around your roof. You also need to make sure that your home has no leaks. This will prevent any water from getting into your home and causing leaks. This is especially important if you live in a moist climate, since standing water in your home is one of the main causes of heat damage.
Another area to look out for is the flooring in your home. Tile is one of the worst things for you to come in contact with, as its porous nature allows for a great deal of sun staining. You need to make sure that the floors around your home are kept as clean as possible. You can do this by sweeping and mopping regularly, as this will keep the area looking nice and fresh.
Patios and decks are also a high risk area for sun damage. If you have a deck, make sure that it is covered when not in use. This will keep the area dry and protect your family from the sun. In addition, protect your furniture from the sun as well. Replacing some area rugs can be enough to reduce damage to furniture.
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Biologics constitute a majority of the top selling drugs of today and also represent one of the fastest growing segments of the overall pharmaceutical industry. In fact, the share of biologics in the overall pharmaceutical market has increased from 16% in 2006 to over 25% in 2017.Having reported over 70% increase in revenues over the past 5-6 years, the market for biologically derived products is currently estimated to be worth more than USD 200 billion.Despite their clinical and commercial success, biopharmaceutical products are associated with high development costs, which are evidently reflected in their prices. Moreover, such therapies are usually designed for intravenous administration, which require a clinical setting (hospitals / infusion centers) for dosing; this further adds to the overall treatment cost. Of late, the subcutaneous route of administration has emerged as a promising and viable approach for the parenteral delivery of biologic drugs. Owing to several compelling advantages, such as patient convenience, potential for self-administration, better therapy adherence and reduced healthcare costs, the concept is steadily gaining traction within the healthcare industry
Tinydale is a well-written parenting blog that gives enormous information about the parents and their newborn kids. In this infographic, you are seeing how one baby starts developing and the different milestones they attain. Get more details by visiting the web page at https://www.tinydale.com/one-month-baby-development/
Individuals who don’t have any improvement in health through normal treatments started looking for alternative treatment methods. Based on philosophy, there is a dynamic balance between internal and external factors of the human body.
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Sleep apnea is a potentially serious sleep disorder in which breathing repeatedly stops and starts. Magniflex helps to provide remedies for sleep apnea.
Knee pain can be experienced by anybody. There are a lot of reasons that cause knee pain. If you’re also the one looking for knee pain solutions, then this post is for you. Knee pain can be due to aging, or it could due to some knee surgery.
The MJPhysio – the best Physio in Vancouver, Surrey, and Fleetwood have come up with the solution to ease your knee pain. Check out the infographic below for different exercises and procedures to perform them. Make sure to take the advice from your specialists before performing the tasks.
Since the success of ADCETRIS® (approved in 2011), antibody drug conjugates (ADCs) are now considered a versatile therapeutic tool and have been accepted into the contemporary portfolio of mainstream healthcare solutions. Over time, clinical researchers have been able to further their understanding of the intricacies of ADC design and have also improved the development process of these complex pharmacological interventions. Some of the recently approved ADC therapeutics include BLENREP® (2020), TRODELVYTM (2020), PadcevTM (2019) and POLIVY® (2019). In addition, there are close to 250 unique ADC product candidates under development. Several big pharma players, including AstraZeneca, GlaxoSmithKline, Pfizer, Roche and Takeda, have also acquired stake in this market. Moreover, the fact that companies involved in the development of ADCs, have received over USD 5 billion in capital investments (since 2011), attests to the therapeutic potential and growing popularity of this novel class of targeted therapeutics. However, the impending growth of the ADC therapeutics market highlights the rising importance of establishing advanced manufacturing capacities in order to meet the anticipated demand. Not all stakeholders in the industry possess end to end capabilities / infrastructure to support the design, development and manufacturing of these complex and highly potent pharmacological entities.
Medical researchers first began evaluating mRNA as a therapeutic modality in the 1990s. The clinical use of mRNA is presently being evaluated in both therapeutic (protein replacement therapies, and as an alternative to classical gene therapies) and preventive (mRNA vaccines) roles. There are over 65 mRNA therapeutics and more than 85 vaccines currently in the development pipeline. As a biomolecule, mRNA is well tolerated in vivo, and (depending on the encoded protein) is capable of inducing humoral and cell-mediated immune responses. Moreover, using this approach, researchers have demonstrated that it is possible to deliver adequate amounts of tumor antigens (bearing patient-specific molecular signatures), and provide the necessary costimulatory signals to mount an effective anticancer immune response. As indicated earlier, mRNA-based interventions are also being evaluated as protein replacement therapies and alternatives to classical gene therapies; however, research on the aforementioned modalities is still in its infancy, with several potential leads in the preclinical stages. Such therapies are predominantly being developed for treating rare disorders. On the other hand, using mRNA, it is possible to develop both personalized (for various cancer) and general-use vaccines (for infectious diseases). Interestingly, mRNA vaccines have shorter development and manufacturing timelines, compared to their traditional counterparts. In fact, Pfizer and BioNtech’s recently approved vaccine (BNT-162) and Moderna’s late phase candidate (mRNA-1273) against the novel coronavirus strain, are both mRNA-based preventive solutions.
One of the most common and normal signs of aging is forgetting things. Besides forgetfulness, people over the age of 60 find it difficult to learn new skills and sometimes even comprehend simple sentences that another person told. There are different levels of cognitive deterioration of senior citizens.
Serious memory problems make it hard to do everyday things like driving and shopping. Signs may include asking the same questions repeatedly, getting lost in familiar places, being unable to follow instructions, and even becoming confused about time, people, and places that they have already encountered.
Some older adults have a mild cognitive impairment, or MCI, meaning they have more memory or other thinking problems than other people their age. People with MCI can usually take care of themselves and do their normal activities. This may be a sign of Alzheimer’s. However, there are people who may just be showing signs of aging.
When diagnosed with MCI, it is important to visit your doctor every six to 12 months to track memory changes and other thinking skills over time. There may be habits and behaviors you can change and activities you can do to maintain memory and thinking skills. Most people who suffer from mild cognitive impairment usually lose their belongings and forget them.
On the other hand, one of the worst conditions that an elderly can face is Dementia, which unlike MCI, it can have worse effects on your everyday life because a person
may forget memories, lose all sense of reasoning, and even problems with language and visual perception. People who have dementia should have Hourly Caregivers in Avon, CT watching out for them.
A live-in caregiver can assist with the medical and non-medical needs of a person. There are differences between normal aging and dementia, and you can check this infographic from Euro-American Connections and Homecare.
The specific ergonomical shape of the pillow supports the head and the neck, allowing for a completely relaxed neck, shoulder and cervical area. An orthopedic pillow is specially designed to provide and support to the neck spine and head. Memoform Magnifoam shapes itself with the pressure and the heat generated by the head and neck as it rests on the pillow. Support is based on the weight added on the pillow, which relaxes the muscles and provides the most comfortable sleep.
Most of your patients want answers for many of their most common health challenges which they face in daily life, and functional medicine is the effective health model that contemporary medical practitioners are using. Millions of people are desperately looking for solutions to their medical issues and expect health-care practitioners who can sit down with them and recommend essential steps to overcome health problems. For more details visit, https://www.goldcoastdigestivehealth.com.au/
As we grow older, it is normal for us people to lose our appetites and excitement for food. It becomes harder to go grocery shopping and cook meals, especially if we do not have anyone else to eat them with. During this time, eating can become more of a chore than something people can look forward to. There are a few signs that a senior may not be eating well. Number one when it comes to this is weight changes. Poor nutrition is usually associated with weight loss, but it is also essential to understand that seniors can be overweight and still be malnourished.
New or worsening health issues may also arise, such as low energy levels, increased falls, confusion, and problems with swallowing or chewing. Another sign of not eating well is the food choices of our beloved seniors. It is important to watch what they eat and guide them to better and healthier choices. Our aging loved ones will naturally care less about food, but we must take it upon ourselves to make sure that they are healthy and proper nutrition is key when it comes to health.
One thing that we can do to help our elders is to find foods that are easy to eat and digest. Doing this ensures less work for them. We must also make sure that these foods are nutritious, high in calories, and hydrating. Lastly, let’s prepare and serve these foods so that our elderly loved ones will look forward to every meal.
A few healthy foods that you can look at; are nut butter, high water content fruits, and vegetables, potatoes, and rolled oats. If you are interested in learning more about how you can provide your elders with healthy meals, here is an infographic by Euro-American Connections and Homecare.